R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

Base Information

Chemical Name:R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol
CAS No.:1338807-91-2
Molecular Formula:C₂₆H₂₅N₂O₄PS
Molecular Weight:492.535
Hs Code.:

Synonyms:R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

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Chemical Property of R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

Chemical Property:

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Technology Process of R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

There total 3 articles about R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18704-37-5
quinoline-8-sulfonyl chloride

: 1338807-90-1
S-2-[R-(diphenylphosphinoyl)-hydroxy-methyl]pyrrolidinium chloride

: 1338807-91-2
R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

Guidance literature:: With potassium carbonate; In dichloromethane; water;
DOI:10.1039/c1ob06143g

Reference yield:

: 4559-70-0
Diphenylphosphine oxide

: 1338807-91-2
R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 24 h / Cooling with ice

2: hydrogenchloride / methanol; water / 24 h / Cooling with ice

3: potassium carbonate / dichloromethane; water

With hydrogenchloride; potassium carbonate; triethylamine; In methanol; dichloromethane; water;
DOI:10.1039/c1ob06143g

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1338807-91-2
R-(diphenylphosphinoyl)-[S-1-(quinoline-8-sulfonyl)pyrrolidin-2-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 24 h / Cooling with ice

2: hydrogenchloride / methanol; water / 24 h / Cooling with ice

3: potassium carbonate / dichloromethane; water

With hydrogenchloride; potassium carbonate; triethylamine; In methanol; dichloromethane; water;
DOI:10.1039/c1ob06143g