2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

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Chemical Name:2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide
CAS No.:323207-22-3
Molecular Formula:C₃₅H₄₇N₅O₇
Molecular Weight:649.787
Hs Code.:

2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

Synonyms:2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

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Chemical Property of 2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

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Technology Process of 2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

There total 7 articles about 2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 75755-40-7
2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

: 323207-41-6
(S)-N-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)proline

: 323207-22-3
2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/1522-2675(20001108)83:11<2961::AID-HLCA2961>3.0.CO;2-S

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 323207-22-3
2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / Et₃N / ethyl acetate / 2 h / 55 °C

2.1: 45 percent / (MeOC₆H₄P(=S)S)2 / toluene / 2 h / Heating

3.1: COCl₂ / CH₂Cl₂; dimethylformamide; toluene / 0.25 h / 20 °C

3.2: DABCO / tetrahydrofuran / 0.67 h / 20 °C

3.3: 74 percent / NaN₃ / tetrahydrofuran / 20 °C

4.1: 71 percent / CH₂Cl₂ / 16 h / 20 °C

5.1: 93 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 1 h / 20 °C

6.1: 71 percent / CH₂Cl₂ / 24 h / 20 °C

With Lawessons reagent; lithium hydroxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1522-2675(20001108)83:11<2961::AID-HLCA2961>3.0.CO;2-S

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 323207-22-3
2-({[(2S)-1-({4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]tetrahydro-2H-pyran-4-yl}carbonyl)pyrrolidin-2-yl]carbonyl}amino)-2,N-dimethyl-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: SOCl₂ / 1 h / Heating

2.1: 89 percent / Et₃N / ethyl acetate / 2 h / 55 °C

3.1: 45 percent / (MeOC₆H₄P(=S)S)2 / toluene / 2 h / Heating

4.1: COCl₂ / CH₂Cl₂; dimethylformamide; toluene / 0.25 h / 20 °C

4.2: DABCO / tetrahydrofuran / 0.67 h / 20 °C

4.3: 74 percent / NaN₃ / tetrahydrofuran / 20 °C

5.1: 71 percent / CH₂Cl₂ / 16 h / 20 °C

6.1: 93 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 1 h / 20 °C

7.1: 71 percent / CH₂Cl₂ / 24 h / 20 °C

With Lawessons reagent; lithium hydroxide; thionyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1522-2675(20001108)83:11<2961::AID-HLCA2961>3.0.CO;2-S