4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin

Base Information

• Chemical Name: 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin
• CAS No.: 1073243-56-7
• Molecular Formula: C₇₂H₇₇N₁₅O₁₄
• Molecular Weight: 1376.5
• Mol file: 1073243-56-7.mol

Synonyms:4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin

Chemical Property of 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin

There total 1 articles about 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeamino-4'-deoxy-4'-oxoparomomycin (1073243-55-6) → 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin (1073243-56-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 26 ℃; for 3h; Inert atmosphere;

DOI:10.1002/hlca.200890167

Reference yield: 75.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin (1073243-56-7) → 4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeamino-4'-O-[(trifluoromethyl)sulfonyl]paromomycin (1073243-59-0)

Guidance literature:

With pyridine; In dichloromethane; at -10 - 20 ℃; for 9.5h; Inert atmosphere;

DOI:10.1002/hlca.200890167

Reference yield: 65.0%

4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeaminoparomomycin (1073243-56-7) → 4'-epi-4'-amino-6,3',6',2,5,3',4'-hepta-O-benzyl-4'-deoxyparomomycin (1073243-54-5)

Guidance literature:

With sodium hydroxide; water; trimethylphosphane; In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1002/hlca.200890167

upstream raw materials:

1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeamino-4'-deoxy-4'-oxoparomomycin

Downstream raw materials:

4'-epi-4'-amino-6,3',6',2,5,3',4'-hepta-O-benzyl-4'-deoxyparomomycin

4'-epi-1,3,2',2',6'-pentaazido-6,3',6',2,5,3',4'-hepta-O-benzyl-1,3,2',2',6'-pentadeamino-4'-O-[(trifluoromethyl)sulfonyl]paromomycin