2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol

Base Information

• Chemical Name: 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol
• CAS No.: 1391914-41-2
• Molecular Formula: C₇H₁₂O₂S₂
• Molecular Weight: 192.303
• Mol file: 1391914-41-2.mol

Synonyms:2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol

Chemical Property of 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Propargyl-PEG1-SS-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG1-SS-alcohol is a Click Chemistry-ready crosslinker containing a propargyl group, a hydroxyl group and a cleavable disulfide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol

There total 3 articles about 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

C12H20O3S2 (1391914-40-1) → 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol (1391914-41-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; dichloromethane; Reflux; Inert atmosphere;

DOI:10.1039/c3cc49790a

Reference yield: 60.0%

bis(2-hydroxyethyl) disulfide (1892-29-1) + propargyl bromide (106-96-7) → 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol (1391914-41-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 9h; Inert atmosphere;

DOI:10.1039/c9cc05859a

Reference yield: 47.0%

bis(2-hydroxyethyl) disulfide (1892-29-1) + 2-propynyl chloride (624-65-7) → 2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethanol (1391914-41-2)

Guidance literature:

bis(2-hydroxyethyl) disulfide; With potassium tert-butylate; In tert-butyl alcohol; at 20 ℃; for 0.75h; Inert atmosphere;

2-propynyl chloride; In tert-butyl alcohol; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1039/d0cc04953k

upstream raw materials:

bis(2-hydroxyethyl) disulfide

propargyl bromide

C₁₂H₂₀O₃S₂

2-propynyl chloride

Refernces

• 1、 Yang, Ruiqi,Dou, Jinkang,Jiang, Li,Chen, Daoyong. "Strictly sparse surface modification and its application for endowing nanoparticles with an exact "valency"". . p. 15553 - 15556. Retrieved 2020.
• 2、 Dhara, Dibakar,Dhara, Santanu,Maiti, Saikat,Maity, Pritiprasanna,Poddar, Puja,Sahoo, Satyagopal. "Synthesis of a new triple-responsive biocompatible block copolymer: Self-assembled nanoparticles as potent anticancer drug delivery vehicle". . . Retrieved 2020.
• 3、 Jung, Danbi,Maiti, Sukhendu,Lee, Jae Hong,Lee, Joung Hae,Kim, Jong Seung. "Rational design of biotin-disulfide-coumarin conjugates: A cancer targeted thiol probe and bioimaging". . p. 3044 - 3047. Retrieved 2014.
• 4、 -. "Pillar aromatic hydrocarbon and pillar aromatic hydrocarbo-like compound with aggregation-induced emission effect as well as preparation method and application thereof". Paragraph 0105; 0109-0111. . Retrieved 2020/12/30.