Technology Process of (S)-3-[(4-bromo-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid
There total 5 articles about (S)-3-[(4-bromo-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane; methoxybenzene;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium hydroxide / water
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 2 °C
3: Dess-Martin periodane / N,N-dimethyl-formamide / 0 - 20 °C
4: trifluoroacetic acid / dichloromethane; methoxybenzene / 0 °C
With
benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide;
In
dichloromethane; water; methoxybenzene; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Dess-Martin periodane / N,N-dimethyl-formamide / 0 - 20 °C
2: trifluoroacetic acid / dichloromethane; methoxybenzene / 0 °C
With
Dess-Martin periodane; trifluoroacetic acid;
In
dichloromethane; methoxybenzene; N,N-dimethyl-formamide;