N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine

Base Information

• Chemical Name: N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine
• CAS No.: 148120-92-7
• Molecular Formula: C₃₀H₃₁N₃O₅
• Molecular Weight: 513.593

Synonyms:N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine

Chemical Property of N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine

Chemical Property:

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Technology Process of N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine

There total 3 articles about N⁴-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N4-acetyl-1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine (148120-91-6) + mono-4-methoxytrityl chloride (14470-28-1) → N4-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine (148120-92-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1021/jm00062a006

Reference yield:

1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine (148120-90-5) → N4-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine (148120-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / methanol / Heating

2: 58 percent / triethylamine / dimethylformamide / 1 h / Ambient temperature

With triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00062a006

Reference yield:

1-<(2,2-dimethyl-1,3-dioxan-5yl)methyl>cytosine (148120-88-1) → N4-acetyl-1-<3-hydroxy-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>prop-1-yl>cytosine (148120-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / hydrogen chloride / methanol / 1.25 h / Ambient temperature

2: 66 percent / methanol / Heating

3: 58 percent / triethylamine / dimethylformamide / 1 h / Ambient temperature

With hydrogenchloride; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00062a006

upstream raw materials:

N⁴-acetyl-1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine

mono-4-methoxytrityl chloride

1-<3-hydroxy-2-(hydroxymethyl)prop-1-yl>cytosine

1-<(2,2-dimethyl-1,3-dioxan-5yl)methyl>cytosine

Downstream raw materials:

(E)-N⁴-acetyl-1-<4-(diphenoxyphosphoryl)-2-<<(4-methoxyphenyl)diphenylmethoxy>methyl>but-3-enyl>cytosine

(E)-1-<4-(diphenoxyphosphoryl)-2-(hydroxymethyl)but-3-enyl>cytosine

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