Benzenamine, 2-((4-methylphenyl)thio)-

Base Information

• Chemical Name: Benzenamine, 2-((4-methylphenyl)thio)-
• CAS No.: 16452-09-8
• Molecular Formula: C13H13 N S
• Molecular Weight: 215.319
• Hs Code.: 2930909090
• Mol file: 16452-09-8.mol

Synonyms:2-Aminophenylp-tolyl sulfide; NSC 136939

Chemical Property of Benzenamine, 2-((4-methylphenyl)thio)-

Chemical Property:

• Vapor Pressure: 4.55E-05mmHg at 25°C
• Boiling Point: 349.9°Cat760mmHg
• Flash Point: 165.4°C
• PSA: 51.32000
• Density: 1.17g/cm³
• LogP: 4.30960

Purity/Quality:

99%min ^*data from raw suppliers

2-(para-Tolylthio)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenamine, 2-((4-methylphenyl)thio)-

There total 12 articles about Benzenamine, 2-((4-methylphenyl)thio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,3-Benzothiazole (95-16-9) + 4-tolyl iodide (624-31-7) → (2-aminophenyl)-4’-methylphenyl sulfide (16452-09-8)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; water; copper(l) chloride; at 50 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.04.004

Reference yield: 95.0%

4-tolyl iodide (624-31-7) + 2-amino-benzenethiol (137-07-5) → (2-aminophenyl)-4’-methylphenyl sulfide (16452-09-8)

Guidance literature:

With 2,2'-biimidazole; copper(II) acetate monohydrate; caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/cjoc.201300830

Reference yield: 86.0%

4-methylphenylboronic acid (5720-05-8) + 2-Aminophenyl disulfide (1141-88-4) → (2-aminophenyl)-4’-methylphenyl sulfide (16452-09-8)

Guidance literature:

With sodium tetrahydroborate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In ethanol; at 20 ℃; for 8h;

DOI:10.1016/j.tet.2014.01.030

upstream raw materials:

2-(4-methylphenylsulfanyl)nitrobenzene

2-allylamino-4'-methyldiphenyl sulphide

2-Chloronitrobenzene

para-thiocresol

Downstream raw materials:

[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-(2-p-tolylsulfanyl-phenyl)-amine

2-methyl-11-phenyl-dibenzo[b,f][1,4]thiazepine

8-methyl-6-phenylphenanthridine

3-methyl-10H-phenothiazine

Refernces

• 1、 Franco, Mario,Vargas, Emily L.,Tortosa, Mariola,Cid. "Coupling of thiols and aromatic halides promoted by diboron derived super electron donors". supporting information. p. 11653 - 11656. Retrieved 2021/11/12.
• 2、 Layek, Samaresh,Agrahari, Bhumika,Dey, Shuvankar,Ganguly, Rakesh,Pathak, Devendra D.. "Copper(II)-faciliated synthesis of substituted thioethers and 5-substituted 1H-tetrazoles: Experimental and theoretical studies". . p. 194 - 206. Retrieved 2019/06/24.