6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride

Base Information

• Chemical Name: 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride
• CAS No.: 1443539-99-8
• Molecular Formula: C₃₂H₃₃NO₄P*Cl
• Molecular Weight: 562.045
• Mol file: 1443539-99-8.mol

Synonyms:6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride

Chemical Property of 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride

There total 5 articles about 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

9-acetoxy-6-(chloromethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine (1443539-97-6) + triphenylphosphine (603-35-0) → 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride (1443539-99-8)

Guidance literature:

In acetonitrile; for 7h; Reflux;

DOI:10.1016/j.bmc.2013.04.051

Reference yield:

6-(hydroxymethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3] dioxepino [5,6-c] pyridin-9-ol (1207071-01-9) → 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride (1443539-99-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 30 h / 20 °C

2: methanesulfonyl chloride / chloroform / 10 h / 0 - 20 °C

3: acetonitrile / 7 h / Reflux

With methanesulfonyl chloride; triethylamine; In dichloromethane; chloroform; acetonitrile;

DOI:10.1016/j.bmc.2013.04.051

Reference yield:

9-acetoxy-6-(hydroxymethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine (1443539-95-4) → 6-[(triphenylphosphonio)methyl]-9-acetoxy-3,3,8-trimethyl-1,5-dihydro[1,3]dioxepino[5,6-c]pyridine chloride (1443539-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonyl chloride / chloroform / 10 h / 0 - 20 °C

2: acetonitrile / 7 h / Reflux

With methanesulfonyl chloride; In chloroform; acetonitrile;

DOI:10.1016/j.bmc.2013.04.051

upstream raw materials:

6-(hydroxymethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3] dioxepino [5,6-c] pyridin-9-ol

9-acetoxy-6-(chloromethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine

triphenylphosphine

9-acetoxy-6-(hydroxymethyl)-3,3,8-trimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine

Downstream raw materials:

6-[(triphenylphosphonio)methyl]-3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium dichloride