2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621886-83-6
Molecular Formula:C₃₂H₂₂F₃N₅O₄S
Molecular Weight:629.619
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 18 articles about 2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1427035-26-4
2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1621888-53-6
2-chloro-11-fluoropyrido[3',2':4,5]pyrimido[1,6-a]indole

: 1621886-83-6
2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 400777-06-2
6-chloro-2-iodopyridin-3-amine

: 1621886-83-6
2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 70 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere; Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate; In 1,4-dioxane; water; 1: |Suzuki Coupling / 3: |Suzuki Coupling;

Reference yield:

: 1432061-90-9
ethyl 6-amino-5-bromobenzofuran-3-carboxylate

: 1621886-83-6
2-(2,4-difluorophenyl)-5-(11-fluoropyrido[3',2':4,5 ]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 2 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 2 h

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / N,N-dimethyl-formamide / 3 h / 15 °C / Inert atmosphere

5.1: pyridine / dichloromethane / 0 - 20 °C

5.2: 1 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / water; 1,4-dioxane / 3 h / 130 °C

8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Suzuki Coupling / 8.1: |Suzuki Coupling;