2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1610033-94-7
Molecular Formula:C₂₅H₂₈ClF₃N₄O₂
Molecular Weight:508.971
Hs Code.:

Synonyms:2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

There total 10 articles about 2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: (3,4-cis)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-ol

: 1610033-08-3
2-((2R,4R)-1-(4-hydroxyphenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

: 1610033-94-7
2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Sonication;

Reference yield:

: 1187449-01-9
2-amino-4-bromo-5-chloropyridine

: 1610033-94-7
2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane / 0.5 h / 0 - 20 °C

1.2: 3.25 h / 20 - 50 °C

2.1: potassium carbonate / dimethyl sulfoxide / 110 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 23 °C

4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / Sonication

With chloro-trimethyl-silane; tetrabutyl ammonium fluoride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: (3,4-cis)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)-3-methylpiperidine

: 1610033-94-7
2-((2R,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 110 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 23 °C

4: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / Sonication

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dimethyl sulfoxide;