3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester

Base Information

• Chemical Name: 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester
• CAS No.: 332095-36-0
• Molecular Formula: C₆₁H₈₆N₁₂O₁₈
• Molecular Weight: 1275.42
• Mol file: 332095-36-0.mol

Synonyms:3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester

Chemical Property of 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester

There total 5 articles about 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoic acid (134568-48-2) + Ethyl 3,5-di(β-aminopropionamido)benzoate dihydrochloride → 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester (332095-36-0)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 48h;

DOI:10.1002/1521-3765(20010202)7:3<686::AID-CHEM686>3.0.CO;2-Z

Reference yield:

3.5-diaminobenzoic acid (535-87-5) → 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester (332095-36-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / H₂SO₄ / 18 h / Heating

2: 80 percent / EEDQ / tetrahydrofuran / 24 h / 20 °C

3: 90 percent / aq. NaOH / methanol; tetrahydrofuran / 12 h / 20 °C

4: 70 percent / DCC; HOBt; DIPEA / dimethylformamide / 48 h / 0 - 20 °C

With sodium hydroxide; sulfuric acid; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/1521-3765(20010202)7:3<686::AID-CHEM686>3.0.CO;2-Z

Reference yield:

3,5-diaminobenzoic acid ethyl ester (1949-51-5) → 3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid ethyl ester (332095-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / EEDQ / tetrahydrofuran / 24 h / 20 °C

2: 90 percent / aq. NaOH / methanol; tetrahydrofuran / 12 h / 20 °C

3: 70 percent / DCC; HOBt; DIPEA / dimethylformamide / 48 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/1521-3765(20010202)7:3<686::AID-CHEM686>3.0.CO;2-Z

upstream raw materials:

3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoic acid

3.5-diaminobenzoic acid

3,5-diaminobenzoic acid ethyl ester

3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoic acid ethyl ester

Downstream raw materials:

3,5-bis-{3-[3,5-bis-(3-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoic acid