2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

Base Information

Chemical Name:2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole
CAS No.:1541186-47-3
Molecular Formula:C₂₃H₂₅N₅O
Molecular Weight:387.484
Hs Code.:

Synonyms:2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

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Chemical Property of 2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

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Technology Process of 2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

There total 4 articles about 2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₉N₅O₂Si

: 1541186-47-3
2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 50 ℃; for 5h;

Reference yield:

: 1541188-13-9
4-{4-[2-(2-trimethylsilanylethoxymethyl)-2H-pyrazol-3-yl]phenoxy}benzene-1,2-diamine

: 1541186-47-3
2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h

1.2: 25 °C

2.1: acetic acid / 5 h / 110 °C

3.1: hydrogenchloride / methanol; 1,4-dioxane / 5 h / 50 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 511237-54-0
C₈H₁₅NO₂

: 1541186-47-3
2-(4-methylpiperidin-1-ylmethyl)-5-[4-(2H-pyrazol-3-yl)phenoxy]-1H-benzoimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h

1.2: 25 °C

2.1: acetic acid / 5 h / 110 °C

3.1: hydrogenchloride / methanol; 1,4-dioxane / 5 h / 50 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; methanol; dichloromethane;