methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

Base Information

Chemical Name:methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate
CAS No.:1360470-68-3
Molecular Formula:C₂₂H₂₅FN₂O₅S
Molecular Weight:448.515
Hs Code.:

Synonyms:methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

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Chemical Property of methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

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Technology Process of methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

There total 7 articles about methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1218918-80-9
C₂₈H₃₉FN₂O₅SSi

: 1360470-68-3
methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

Guidance literature:: With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1218918-76-3
dimethyl (2R)-2-[[(4-fluorophenyl)sulfonyl]amino]-butanedioate

: 1360470-68-3
methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 16 h / 0 °C / Inert atmosphere

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 1 h / Inert atmosphere

3.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: potassium hexamethylsilazane / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

4.2: 1.67 h / Inert atmosphere

4.3: 1 h / Inert atmosphere

5.1: hydrogenchloride; water / N,N-dimethyl-formamide / 2 h / 16 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tributylphosphine; water; potassium hexamethylsilazane; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1021/jo202620r

Reference yield:

: 1218918-77-4
N-[(2R)-1,4-dihydroxybutan-2-yl]-4-fluorobenzenesulfonamide

: 1360470-68-3
methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 1 h / Inert atmosphere

2.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

3.2: 1.67 h / Inert atmosphere

3.3: 1 h / Inert atmosphere

4.1: hydrogenchloride; water / N,N-dimethyl-formamide / 2 h / 16 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; tributylphosphine; water; potassium hexamethylsilazane; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;
DOI:10.1021/jo202620r