3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

Base Information

Chemical Name:3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline
CAS No.:1195768-90-1
Molecular Formula:C₁₇H₁₇ClN₄OS
Molecular Weight:360.867
Hs Code.:

Synonyms:3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

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Chemical Property of 3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

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Technology Process of 3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

There total 7 articles about 3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.8%

: 1195768-89-8
2-propen-1-yl [3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)phenyl]carbamate

: 1195768-90-1
3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

Guidance literature:: 2-propen-1-yl [3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)phenyl]carbamate; With tri-n-butyl-tin hydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 5129-25-9
2-methoxy-3-methoxycarbonylaniline

: 1195768-90-1
3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

2.2: 1.33 h / 0 - 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C

3.2: 1 h / 20 °C

4.1: tri-n-butyl-tin hydride; acetic acid / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0 - 20 °C

With N-Bromosuccinimide; tri-n-butyl-tin hydride; sodium hydrogencarbonate; acetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1195768-87-6
methyl 2-(methyloxy)-3-{[(2-propen-1-yloxy)carbonyl]amino}benzoate

: 1195768-90-1
3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-(methyloxy)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

1.2: 1.33 h / 0 - 20 °C

2.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: tri-n-butyl-tin hydride; acetic acid / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0 - 20 °C

With N-Bromosuccinimide; tri-n-butyl-tin hydride; acetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane;