3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester

Base Information

• Chemical Name: 3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester
• CAS No.: 914979-60-5
• Molecular Formula: C₁₅H₁₆BrNO₆
• Molecular Weight: 386.199
• Mol file: 914979-60-5.mol

Synonyms:3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester

Chemical Property of 3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester

There total 2 articles about 3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

nitroacetic acid ethyl ester (626-35-7) + methyl 2-(acetoxy-(4-bromophenyl)methyl)acrylate (845866-13-9) → 3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester (914979-60-5)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2006.08.045

Reference yield:

2-[(4-bromo-phenyl)-hydroxy-methyl]-acrylic acid methyl ester (251320-24-8) → 3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester (914979-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 72 percent / DABCO / tetrahydrofuran; H₂O / 4 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.tet.2006.08.045

Reference yield: 73.0%

3-(4-bromophenyl)-2-methylene-4-nitro-pentanedioic acid 5-ethyl ester 1-methyl ester (914979-60-5) → 3-(4-bromophenyl)-2-hydroxyimino-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:

With tin(ll) chloride; In methanol; at 80 ℃; for 1.5h;

DOI:10.1016/j.tet.2006.08.045

upstream raw materials:

nitroacetic acid ethyl ester

methyl 2-(acetoxy-(4-bromophenyl)methyl)acrylate

2-[(4-bromo-phenyl)-hydroxy-methyl]-acrylic acid methyl ester