tri-O-benzoyl-5-iodo-2'-C-methyluridine

Base Information

• Chemical Name: tri-O-benzoyl-5-iodo-2'-C-methyluridine
• CAS No.: 1203461-95-3
• Molecular Formula: C₃₁H₂₅IN₂O₉
• Molecular Weight: 696.452
• Mol file: 1203461-95-3.mol

Synonyms:tri-O-benzoyl-5-iodo-2'-C-methyluridine

Chemical Property of tri-O-benzoyl-5-iodo-2'-C-methyluridine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of tri-O-benzoyl-5-iodo-2'-C-methyluridine

There total 1 articles about tri-O-benzoyl-5-iodo-2'-C-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-iodouracil (696-07-1) + 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose (15397-15-6) → tri-O-benzoyl-5-iodo-2'-C-methyluridine (1203461-95-3)

Guidance literature:

5-iodouracil; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 20 ℃; for 0.333333h;

1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose; With tin(IV) chloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1080/15257770903128870

Reference yield: 90.0%

tri-O-benzoyl-5-iodo-2'-C-methyluridine (1203461-95-3) → 5-iodo-2'-C-methyluridine (1203461-96-4)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 24h;

DOI:10.1080/15257770903128870

Reference yield:

1-decyne (764-93-2) + tri-O-benzoyl-5-iodo-2'-C-methyluridine (1203461-95-3) → 3-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-6-octyl-2,3-dihydro-furo[2,3-d]-pyrimidin-2(1H)-one (1203462-00-3)

Guidance literature:

With copper(l) iodide; palladium 10% on activated carbon; triethylamine; In acetonitrile; at 80 ℃; for 5h; Inert atmosphere;

DOI:10.1080/15257770903128870

upstream raw materials:

5-iodouracil

1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose

Downstream raw materials:

3-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-6-octyl-2,3-dihydro-furo[2,3-d]-pyrimidin-2(1H)-one

5-dec-1-yn-1-yl-2',3',5'-tri-O-benzoyl-2'-C-methyluridine

5-iodo-2'-C-methyluridine

3-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-6-decyl-2,3-dihydro-furo[2,3-d]-pyrimidin-2(1H)-one