C₂₅H₄₃BOSi

Base Information

• Chemical Name: C₂₅H₄₃BOSi
• CAS No.: 1362209-51-5
• Molecular Formula: C₂₅H₄₃BOSi
• Molecular Weight: 398.512
• Mol file: 1362209-51-5.mol

Synonyms:C₂₅H₄₃BOSi

Chemical Property of C₂₅H₄₃BOSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₄₃BOSi

There total 1 articles about C₂₅H₄₃BOSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-ene (1287305-45-6) + 9-bora-bicyclo[3.3.1]nonane (280-64-8) → C25H43BOSi (1362209-51-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/ol300431n

Reference yield:

(1S,4S)-4-((p-methoxybenzyloxy)methoxy)-3-iodocyclopent-2-enol (1362209-48-0) + C25H43BOSi (1362209-51-5) → (1S,4S)-4-((p-methoxybenzyloxy)methoxy)-3-((S)-3-(tert-butyldimethylsilyloxy)-5-phenylpentyl)cyclopent-2-enol (1362209-54-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/ol300431n

Reference yield:

C25H43BOSi (1362209-51-5) → C32H39Cl3N2O9S

Guidance literature:

Multi-step reaction with 7 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / -30 - -10 °C

3: potassium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 0.33 h / 170 °C

4: pyridine hydrogenfluoride / acetonitrile / 1 h / 20 °C

5: sulphamoyl chloride / N,N-dimethyl acetamide; acetonitrile / 0.25 h / 20 °C

6: dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide / dichloromethane / 1 h / 40 °C

7: dmap; triethylamine / tetrahydrofuran / 1.5 h / 20 °C

With dmap; dirhodium tetraacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; sulphamoyl chloride; magnesium oxide; potassium carbonate; pyridine hydrogenfluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl acetamide; acetonitrile; 1: Suzuki-Miyaura coupling / 3: Overman rearrangement;

DOI:10.1021/ol300431n

upstream raw materials:

(R)-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-ene

9-bora-bicyclo[3.3.1]nonane

Downstream raw materials:

(1S,4S)-4-((p-methoxybenzyloxy)methoxy)-3-((S)-3-(tert-butyldimethylsilyloxy)-5-phenylpentyl)cyclopent-2-enol

tert-butyl ((S)-2-((2R,5S,9S)-9-hydroxy-1-(2,2,2-trichloroacetyl)-1-azaspiro[4.4]non-6-en-2-yl)-1-phenylethyl)carbamate

tert-butyl ((S)-2-((2R,5S,9S)-9-(carbamoyloxy)-1-(2,2,2-trichloroacetyl)-1-azaspiro[4.4]non-6-en-2-yl)-1-phenylethyl)carbamate

tert-butyl ((S)-2-((2'S,3aS,5'R,6aS)-2-oxo-1'-(2,2,2-trichloroacetyl)-2,3,3a,6a-tetrahydrospiro[cyclopenta[d]oxazole-6,2'-pyrrolidin]-5'-yl)-1-phenylethyl)carbamate