2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Base Information

• Chemical Name: 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole
• CAS No.: 1269439-95-3
• Molecular Formula: C₂₈H₃₀N₆O₃
• Molecular Weight: 498.585

Synonyms:2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Chemical Property of 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

Chemical Property:

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Technology Process of 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole

There total 7 articles about 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carbaldehyde (1269439-92-0) + 4-(4-methylpiperazino)-1,2-diaminobenzene (54998-08-2) → 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole (1269439-95-3)

Guidance literature:

With sodium metabisulfite; In ethanol; water; for 6h; Reflux;

DOI:10.1016/j.ejmech.2010.11.046

Reference yield:

1-methyl-piperazine (109-01-3) → 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole (1269439-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 110 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr

3: sodium metabisulfite / ethanol; water / 6 h / Reflux

With sodium metabisulfite; palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.11.046

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 2-(3,4,5-trimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazole (1269439-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 110 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr

3: sodium metabisulfite / ethanol; water / 6 h / Reflux

With sodium metabisulfite; palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.11.046

upstream raw materials:

1-methyl-piperazine

5-cyano-2-(3,4,5-trimethoxyphenyl)benzimidazole

2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carbaldehyde

4-(4-methylpiperazino)-1,2-diaminobenzene

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