3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Base Information

Chemical Name:3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
CAS No.:74655-31-5
Molecular Formula:C₂₂H₂₄ClNO₅
Molecular Weight:417.889
Hs Code.:
NSC Number:362409

Synonyms:74655-31-5;NSC362409;NSC 362409;3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate;NSC-362409;O3-isopropyl O5-methyl 4-(2-chlorophenyl)-2-methyl-6-[(E)-3-oxobut-1-enyl]-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of 3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Chemical Property:

Vapor Pressure:1.38E-11mmHg at 25°C
Boiling Point:536.6°C at 760 mmHg
Flash Point:278.3°C
Density:1.246g/cm³
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:417.1343006
Heavy Atom Count:29
Complexity:765

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C=CC(=O)C)C(=O)OC)C2=CC=CC=C2Cl)C(=O)OC(C)C
Isomeric SMILES:CC1=C(C(C(=C(N1)/C=C/C(=O)C)C(=O)OC)C2=CC=CC=C2Cl)C(=O)OC(C)C

Technology Process of 3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

There total 6 articles about 3-Isopropyl 5-methyl 4-(2-chlorophenyl)-2-methyl-6-(3-oxo-1-butenyl)-1,4-dihydro-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 75090-95-8
4-(2-Chloro-phenyl)-2-formyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-isopropyl ester 3-methyl ester

: 1439-36-7
1-triphenylphosphoranylidene-2-propanone

: 140230-85-9,74655-31-5
4-(2-Chloro-phenyl)-2-methyl-6-((E)-3-oxo-but-1-enyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester

Guidance literature:: In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.3189

Reference yield:

: 60705-25-1
4,4-dimethoxy-3-oxo-butyric acid methyl ester

: 140230-85-9,74655-31-5
4-(2-Chloro-phenyl)-2-methyl-6-((E)-3-oxo-but-1-enyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / benzene / 3 h / Heating

2: 59.3 percent / 8.5 h / 95 - 120 °C

3: 76.1 percent / 6 N aq. HCl / acetone / 1 h / Ambient temperature

4: 75 percent / CH₂Cl₂ / 1 h / Ambient temperature

With piperidine; hydrogenchloride; In dichloromethane; acetone; benzene;
DOI:10.1248/cpb.39.3189

Reference yield:

: 14205-46-0
isopropyl 3-aminocrotonate

: 140230-85-9,74655-31-5
4-(2-Chloro-phenyl)-2-methyl-6-((E)-3-oxo-but-1-enyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 59.3 percent / 8.5 h / 95 - 120 °C

2: 76.1 percent / 6 N aq. HCl / acetone / 1 h / Ambient temperature

3: 75 percent / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; In dichloromethane; acetone;
DOI:10.1248/cpb.39.3189