(+)-allo-eleutherin

Base Information

• Chemical Name: (+)-allo-eleutherin
• CAS No.: 1078723-14-4
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.301
• Mol file: 1078723-14-4.mol

Synonyms:(+)-allo-eleutherin

Chemical Property of (+)-allo-eleutherin

Chemical Property:

Purity/Quality:

≥98% ^*data from raw suppliers

Isoeleutherin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-allo-eleutherin

There total 5 articles about (+)-allo-eleutherin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1S,3S)-5,9,10-trimethoxy-1,3-dimethyl-3,4-dihydro-1H-benzo[g]isochromene (1078723-20-2) → (+)-allo-eleutherin (1078723-14-4)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2008.08.065

Reference yield:

(2S)-tert-butyldimethyl-[1-(1,4,5-trimethoxynaphthalen-2-yl)propan-2-yloxy]silane (1078723-18-8) → (+)-allo-eleutherin (1078723-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

1.2: 0.5 h

2.1: boron trifluoride diethyl etherate / dichloromethane / 10 h / 20 °C / Inert atmosphere

3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 20 °C

With ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1016/j.tetasy.2011.02.011

Reference yield:

(2S)-1-(1,4,5-trimethoxynaphthalen-2-yl)propan-2-ol (1078723-19-9) → (+)-allo-eleutherin (1078723-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 10 h / 20 °C / Inert atmosphere

2: ammonium cerium (IV) nitrate / water; acetonitrile / 1 h / 20 °C

With ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; In dichloromethane; water; acetonitrile;

DOI:10.1016/j.tetasy.2011.02.011

upstream raw materials:

(1S,3S)-5,9,10-trimethoxy-1,3-dimethyl-3,4-dihydro-1H-benzo[g]isochromene

(2S)-tert-butyldimethyl-[1-(1,4,5-trimethoxynaphthalen-2-yl)propan-2-yloxy]silane

(2S)-1-(1,4,5-trimethoxynaphthalen-2-yl)propan-2-ol

(2S)-2-(2-(tert-butyldimethylsilyloxy)propyl)-4,5-dimethoxynaphthalen-1-ol