2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

Base Information

Chemical Name:2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide
CAS No.:1354721-95-1
Molecular Formula:C₂₁H₂₁F₃N₆O
Molecular Weight:430.433
Hs Code.:

Synonyms:2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

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Chemical Property of 2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

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Technology Process of 2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

There total 5 articles about 2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1354721-94-0
2-nitro-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

: 1354721-95-1
2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1354721-95-1
2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; copper diacetate / dichloromethane / 30 °C / Molecular sieve

2: hydrogen / palladium on activated charcoal / methanol / 3 h / 25 °C

3: pyridine / dichloromethane / 2 h / 0 - 5 °C

4: potassium carbonate / N,N-dimethyl-formamide / 90 °C

5: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With pyridine; hydrogen; copper diacetate; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1354721-93-9
5-chloro-2-nitro-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

: 1354721-95-1
2-amino-5-(piperidin-1-yl)-N-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 90 °C

2: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;