(3R,4S)-4-aMino-3-hydroxy-2,2-diMethylchroMan-6-carbonitrile

Base Information

• Chemical Name: (3R,4S)-4-aMino-3-hydroxy-2,2-diMethylchroMan-6-carbonitrile
• CAS No.: 127419-05-0
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.255
• Mol file: 127419-05-0.mol

Synonyms:(3R-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

Chemical Property of (3R,4S)-4-aMino-3-hydroxy-2,2-diMethylchroMan-6-carbonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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Technology Process of (3R,4S)-4-aMino-3-hydroxy-2,2-diMethylchroMan-6-carbonitrile

There total 5 articles about (3R,4S)-4-aMino-3-hydroxy-2,2-diMethylchroMan-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1aR,7bS)-2,2-Dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile → (3R-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (127419-05-0)

Guidance literature:

With ammonium hydroxide; In ethanol; Ambient temperature;

DOI:10.1021/jm00076a027

Reference yield:

(1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno[c][1]benzopyran-6-carbonitrile (65018-90-8,75611-72-2,114926-02-2,114926-03-3) → (3R-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (127419-05-0)

Guidance literature:

With ammonia; In ethanol;

DOI:10.1021/jm960535w

Reference yield:

6-cyano-3,4-dihydro-2,2-dimethyl-trans-3-bromo-4-hydroxy-2H-1-benzopyran (114865-21-3) → (3R-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (127419-05-0)

Guidance literature:

With ammonium hydroxide; aq. sodium hydroxide; In tetrahydrofuran; ethanol;

upstream raw materials:

(1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno[c][1]benzopyran-6-carbonitrile

6-cyano-3,4-dihydro-2,2-dimethyl-trans-3-bromo-4-hydroxy-2H-1-benzopyran

[3R-[3α,4β(S*)]]-N-(6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-α-hydroxybenzeneacetamide

Downstream raw materials:

(3S-trans)-3-[[[(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl) amino]carbonyl]amino]benzeneacetic acid, methyl ester

cromakalim

ethyl N-acetyl-4-fluorobenzimidate

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