18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

Base Information

Chemical Name:18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine
CAS No.:120385-46-8
Molecular Formula:C₃₀H₃₄N₂O₅S
Molecular Weight:534.676
Hs Code.:

$18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine$

Synonyms:18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

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Chemical Property of 18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

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Technology Process of 18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

There total 3 articles about 18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89240-74-4
(3aR,10bR,12bS)-2,3,3a,11,12,12b-Hexahydro-1H,6H-6,12a-diaza-indeno[7,1-cd]fluoren-4-one

$18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine$: 120385-46-8
18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / 1.) tetrabutylammonium hydrogen sulfate, NaOH / 1.) H₂O, Ch₂Cl₂, RT, 10 min, 2.) 0.5 h

2: 1.) potassium hydride / 1.) THF, 0 deg C, 0.5 h, 2.) 0.5 h

3: 91 percent / CH₂Cl₂ / 120 h / Ambient temperature

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium hydride; In dichloromethane;
DOI:10.1021/jo00274a051

Reference yield:

: 120385-49-1
(3aS,10bS,12bR)-6-(Toluene-4-sulfonyl)-2,3,3a,11,12,12b-hexahydro-1H,6H-6,12a-diaza-indeno[7,1-cd]fluoren-4-one

$18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine$: 120385-46-8
18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium hydride / 1.) THF, 0 deg C, 0.5 h, 2.) 0.5 h

2: 91 percent / CH₂Cl₂ / 120 h / Ambient temperature

With potassium hydride; In dichloromethane;
DOI:10.1021/jo00274a051

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

$18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine$: 120385-46-8
18(R)-carbomethoxy-16,17-didehydro-17-ethoxy-1-(p-tolylsulfonyl)aspidofractinine

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / 1.) tetrabutylammonium hydrogen sulfate, NaOH / 1.) H₂O, Ch₂Cl₂, RT, 10 min, 2.) 0.5 h

2: 1.) potassium hydride / 1.) THF, 0 deg C, 0.5 h, 2.) 0.5 h

3: 91 percent / CH₂Cl₂ / 120 h / Ambient temperature

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium hydride; In dichloromethane;
DOI:10.1021/jo00274a051