N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

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Chemical Name:N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide
CAS No.:960371-06-6
Molecular Formula:C₂₆H₂₉F₄NO₃
Molecular Weight:479.515
Hs Code.:

Synonyms:N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

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Chemical Property of N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

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Technology Process of N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

There total 3 articles about N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 917771-46-1
(S)-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl) benzoic acid

: ((1S,4S)-4-(cyclopropylamino)-1-(4-fluorophenyl)cyclohexyl)methanol

: 960371-06-6
N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml500331y

Reference yield:

: 61779-03-1
4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexanone

: 960371-06-6
N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / acetonitrile / 12 h / 0 - 25 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml500331y

Reference yield:

: 917771-46-1
(S)-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl) benzoic acid

: C₁₆H₂₂FNO

: 960371-06-6
N-cyclopropyl-N-((1S,4S)-4-(4-fluorophenyl)-4-(hydroxymethyl)cyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.10.129