2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine

Base Information

• Chemical Name: 2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine
• CAS No.: 1393670-38-6
• Molecular Formula: C₂₂H₃₄N₄O₄
• Molecular Weight: 418.536
• Mol file: 1393670-38-6.mol

Synonyms:2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine

Chemical Property of 2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine

There total 2 articles about 2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,3-di(tert-butoxycarbonyl)-4-methylimidazolidine-2-thione (1393670-62-6) + 4-amino-N,N-dimethylaniline (99-98-9) → 2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine (1393670-38-6)

Guidance literature:

With triethylamine; mercury dichloride; In dichloromethane; at 0 - 20 ℃; for 17h;

DOI:10.1016/j.tetlet.2012.06.042

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine (1393670-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

1.2: 2.5 h

2.1: mercury dichloride; triethylamine / dichloromethane / 17 h / 0 - 20 °C

With sodium hydride; triethylamine; mercury dichloride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1016/j.ejmech.2014.05.057

Reference yield: 71.0%

2-[(4-dimethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine (1393670-38-6) → 4-dimethylamino-N-(4-methylimidazolidin-2-ylidene)aniline hydrochloride (1393670-32-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 55 ℃; for 3h;

DOI:10.1016/j.tetlet.2012.06.042

upstream raw materials:

1,3-di(tert-butoxycarbonyl)-4-methylimidazolidine-2-thione

4-amino-N,N-dimethylaniline

di-tert-butyl dicarbonate

Downstream raw materials:

4-dimethylamino-N-(4-methylimidazolidin-2-ylidene)aniline hydrochloride