3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

Base Information

Chemical Name:3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene
CAS No.:606123-19-7
Molecular Formula:C₂₂H₂₈F₂O₂S
Molecular Weight:394.526
Hs Code.:

Synonyms:3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

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Chemical Property of 3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

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Technology Process of 3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

There total 6 articles about 3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4347-31-3
2-formylthiophene-3-boronic acid

: 606123-18-6
3,5-di-tert-butyl-2-(3,3-difluoropropoxy)iodobenzene

: 606123-19-7
3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 90 ℃; for 15h;
DOI:10.1021/jm020401k

Reference yield:

: 96-76-4
2,4-di-tert-Butylphenol

: 606123-19-7
3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / N-iodosuccinimide; p-toluenesulfonic acid / CH₂Cl₂ / 20 °C

2: NaH / dimethylformamide / 0 - 20 °C

3: 9.1 mmol / TBAF / tetrahydrofuran

4: 65 percent / PCC; Celite; MS / CH₂Cl₂ / 20 °C

5: 88 percent / DAST / CH₂Cl₂ / 20 °C

6: 80 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 15 h / 90 °C

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Celite; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6: Suzuki coupling;
DOI:10.1021/jm020401k

Reference yield:

: 89209-02-9
4,6-di-tert-butyl-2-iodophenol

: 606123-19-7
3-[3,5-di-tert-butyl-2-(3,3-difluoropropoxy)benzene]-2-formylthiophene

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide / 0 - 20 °C

2: 9.1 mmol / TBAF / tetrahydrofuran

3: 65 percent / PCC; Celite; MS / CH₂Cl₂ / 20 °C

4: 88 percent / DAST / CH₂Cl₂ / 20 °C

5: 80 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 15 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Celite; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; 4,4'-diaminostilbene-2,2'-disulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5: Suzuki coupling;
DOI:10.1021/jm020401k