methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Base Information

Chemical Name:methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate
CAS No.:231296-76-7
Molecular Formula:C₁₈H₁₉NO₅S
Molecular Weight:361.419
Hs Code.:

Synonyms:methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

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Chemical Property of methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Chemical Property:

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Technology Process of methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

There total 3 articles about methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 231296-75-6
methyl (2E)-3-(2-amino-4-methoxyphenyl)acrylate

: 98-59-9
p-toluenesulfonyl chloride

: 231296-76-7
methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.01.053

Reference yield:

: 231296-75-6
methyl (2E)-3-(2-amino-4-methoxyphenyl)acrylate

: 231296-76-7
methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Guidance literature:

Reference yield:

: 5344-78-5
4-bromo-3-nitroanizole

: 231296-76-7
methyl (2E)-3-(4-methoxy-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 130 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 2 h / Reflux; Inert atmosphere

3: pyridine / dichloromethane / 10 h / 20 °C / Inert atmosphere

With pyridine; palladium diacetate; iron; ammonium chloride; triethylamine; triphenylphosphine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Heck-Mizoroki cross-coupling;
DOI:10.1016/j.ejmech.2012.01.053