4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

Base Information

Chemical Name:4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde
CAS No.:245662-12-8
Molecular Formula:C₂₀H₁₆N₂O₅S
Molecular Weight:396.423
Hs Code.:

Synonyms:4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

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Chemical Property of 4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

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Technology Process of 4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

There total 10 articles about 4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 245662-11-7
Methyl 4-methoxy-8-tosyloxy-β-carboline-1-carboxylate

: 245662-12-8
4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -50 ℃; for 0.0833333h;

Reference yield:

: 126260-57-9
Ethyl 7-tosyloxyindole-2-carboxylate

: 245662-12-8
4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / DIBAL-H / CH₂Cl₂ / 0.08 h / -78 °C

2.1: 89 percent / MnO₂ / CH₂Cl₂ / 3 h / 20 °C

3.1: 79 percent / Et₃N; NaBH₃CN / methanol / 24 h / 20 °C

4.1: 100 percent / HCOOH / 24 h / 20 °C

5.1: 80 percent / MsOH / 8 h / 55 °C

6.1: p-TsOH / benzene / 0.5 h / 20 °C

6.2: 70 percent / chloranil / benzene / 12 h / 20 °C

7.1: 98 percent / MCPBA / CH₂Cl₂ / 24 h / 20 °C

8.1: 65 percent / Et₃N / 1,2-dichloro-ethane / 2 h / 80 °C

9.1: 80 percent / HCl / 5 h / Heating

10.1: 80 percent / DIBAL-H / CH₂Cl₂ / 0.08 h / -50 °C

With hydrogenchloride; manganese(IV) oxide; formic acid; methanesulfonic acid; diisobutylaluminium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; benzene; 1.1: Reduction / 2.1: Oxidation / 3.1: Condensation / 4.1: Formylation / 5.1: Cyclization / 6.1: Substitution / 6.2: Oxidation / 7.1: Oxidation / 8.1: Substitution / 9.1: Substitution / 10.1: Reduction;

Reference yield:

: 245662-02-6
7-Tosyloxyindole-2-carbaldehyde

: 245662-12-8
4-Methoxy-8-tosyloxy-β-carboline-1-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / Et₃N; NaBH₃CN / methanol / 24 h / 20 °C

2.1: 100 percent / HCOOH / 24 h / 20 °C

3.1: 80 percent / MsOH / 8 h / 55 °C

4.1: p-TsOH / benzene / 0.5 h / 20 °C

4.2: 70 percent / chloranil / benzene / 12 h / 20 °C

5.1: 98 percent / MCPBA / CH₂Cl₂ / 24 h / 20 °C

6.1: 65 percent / Et₃N / 1,2-dichloro-ethane / 2 h / 80 °C

7.1: 80 percent / HCl / 5 h / Heating

8.1: 80 percent / DIBAL-H / CH₂Cl₂ / 0.08 h / -50 °C

With hydrogenchloride; formic acid; methanesulfonic acid; diisobutylaluminium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; benzene; 1.1: Condensation / 2.1: Formylation / 3.1: Cyclization / 4.1: Substitution / 4.2: Oxidation / 5.1: Oxidation / 6.1: Substitution / 7.1: Substitution / 8.1: Reduction;