4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

Base Information

Chemical Name:4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B
CAS No.:142859-94-7
Molecular Formula:C₆₆H₇₃F₂N₅O₂₂
Molecular Weight:1326.32
Hs Code.:

Synonyms:4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

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Chemical Property of 4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

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Technology Process of 4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

There total 3 articles about 4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 142906-20-5
4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5-oxokanamycin B

: 142859-94-7
4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; for 8h; Ambient temperature;
DOI:10.1016/0008-6215(92)80060-E

Reference yield:

: 142859-93-6
4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3'-deoxykanamycin B

: 142859-94-7
4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / pyridinium chlorochromate, molecular sieves 3A / 72 h / Ambient temperature

2: 67 percent / DAST / CH₂Cl₂ / 8 h / Ambient temperature

With 3 A molecular sieve; 4,4'-diaminostilbene-2,2'-disulfonic acid; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/0008-6215(92)80060-E

Reference yield:

: 61093-69-4
1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3'-deoxykanamycin B

: 142859-94-7
4',2'',4'',6''-tetra-O-acetyl-1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-5,3'-dideoxy-5,5-difluorokanamycin B

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / Ambient temperature

2: 75 percent / pyridinium chlorochromate, molecular sieves 3A / 72 h / Ambient temperature

3: 67 percent / DAST / CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; 3 A molecular sieve; 4,4'-diaminostilbene-2,2'-disulfonic acid; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/0008-6215(92)80060-E