4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Base Information

Chemical Name:4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester
CAS No.:916431-28-2
Molecular Formula:C₂₀H₂₇N₃O₄
Molecular Weight:373.452
Hs Code.:

4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid <i>tert</i>-butyl ester

Synonyms:4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Suppliers and Price of 4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

There total 4 articles about 4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 380649-36-5
(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)acetic acid tert-butyl ester

: 916431-28-2
4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: TFA

2.1: i-BuOCOCl; NMM / tetrahydrofuran / 0.42 h / -20 °C

2.2: 50 percent / NaBH₄ / H₂O; tetrahydrofuran / 0.33 h / -20 °C

3.1: oxalyl chloride; DMSO; DIPEA / CH₂Cl₂ / -20 - 20 °C

4.1: 93.5 mg / CH₂Cl₂ / 2.5 h / 20 °C

With 4-methyl-morpholine; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; 3.1: Swern oxidation / 4.1: Wittig reaction;
DOI:10.1021/jm0606589

Reference yield:

: 916430-97-2
(6-benzyl-1-methyl-4,7-dioxo[1,3,5]triazepan-3-yl)acetic acid

: 916431-28-2
4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: i-BuOCOCl; NMM / tetrahydrofuran / 0.42 h / -20 °C

1.2: 50 percent / NaBH₄ / H₂O; tetrahydrofuran / 0.33 h / -20 °C

2.1: oxalyl chloride; DMSO; DIPEA / CH₂Cl₂ / -20 - 20 °C

3.1: 93.5 mg / CH₂Cl₂ / 2.5 h / 20 °C

With 4-methyl-morpholine; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation / 3.1: Wittig reaction;
DOI:10.1021/jm0606589

Reference yield:

: 916430-98-3
7-benzyl-3-(2-hydroxy-ethyl)-5-methyl-[1,3,5]triazepane-2,6-dione

: 916431-28-2
4-(6-benzyl-1-methyl-4,7-dioxo-[1,3,5]triazepan-3-yl)-but-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMSO; DIPEA / CH₂Cl₂ / -20 - 20 °C

2: 93.5 mg / CH₂Cl₂ / 2.5 h / 20 °C

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Swern oxidation / 2: Wittig reaction;
DOI:10.1021/jm0606589