(2R,3R)-1,1-dioxido-2-(propan-2-yl)tetrahydrothiophen-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

Base Information

Chemical Name:(2R,3R)-1,1-dioxido-2-(propan-2-yl)tetrahydrothiophen-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate
CAS No.:147977-21-7
Molecular Formula:C₃₂H₅₁N₃O₆S
Molecular Weight:605.839
Hs Code.:

(2R,3R)-1,1-dioxido-2-(propan-2-yl)tetrahydrothiophen-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

Synonyms:Carbamicacid,[3-[3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-,tetrahydro-2-(1-methylethyl)-3-thienyl ester, S,S-dioxide, [3S-[2[1R*(2R*,3R*),2S*],3a,4ab,8ab]]-; Carbamic acid,[3-[3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-,tetrahydro-2-(1-methylethyl)-1,1-dioxido-3-thienyl ester,[3S-[2[1R*(2R*,3R*),2S*],3a,4ab,8ab]]-

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Chemical Property of (2R,3R)-1,1-dioxido-2-(propan-2-yl)tetrahydrothiophen-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

Chemical Property:

Vapor Pressure:4.1E-28mmHg at 25°C
Boiling Point:815.4°C at 760 mmHg
Flash Point:446.9°C
PSA：140.40000
Density:1.21g/cm³
LogP:5.75530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,3R)-1,1-dioxido-2-(propan-2-yl)tetrahydrothiophen-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate

There total 24 articles about (2R,3R)-1,1-dioxido-2-(propan-2-yl)tetrahydrothiophen-3-yl {(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 147949-28-8
[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2R,3R)-2-isopropyl-tetrahydro-thiophen-3-yl ester

: 147977-21-7
L-735,489

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; at 24 ℃; for 12h;
DOI:10.1021/jm00034a016

Reference yield:

: [(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid (2S,3S)-2-isopropyl-tetrahydro-thiophen-3-yl ester

: 147977-21-7
N-tert-butyldecahydro-2-<2(R)-hydroxy-4-phenyl-3(S)-<<<<2'(S)-(1-methylethyl)-(3'S)-1',1'-dioxotetrahydrothiophene-3'-yl>oxy>carbonyl>amino>butyl>-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone;
DOI:10.1021/jm00059a019

Reference yield:

: 136465-89-9
(2S)-2-[1'(S)-1-azido-2-phenylethyl]oxirane

: 147977-21-7
L-735,489

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / propan-2-ol / 80 °C

2: H₂, AcOH / 10percent Pd/C / methanol; tetrahydrofuran

3: 65 percent / CH₂Cl₂ / 12 h / 24 °C

4: 92 percent / OsO₄, 4-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 12 h / 24 °C

With osmium(VIII) oxide; hydrogen; acetic acid; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; acetone; tert-butyl alcohol;
DOI:10.1021/jm00034a016