6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Base Information

Chemical Name:6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one
CAS No.:367518-86-3
Molecular Formula:C₄₄H₅₁N₅O₁₀Si
Molecular Weight:838.002
Hs Code.:

6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Synonyms:6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Suppliers and Price of 6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

There total 9 articles about 6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 367518-77-2
6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-2-amino-5-nitropyrimidine-3H-4-one

: 122-59-8
2-phenoxyacetic acid

: 367518-86-3
6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ja0160952 DOI:10.1021/ja012135q

Reference yield:

: 418760-15-3
2-deoxy-α,β-D-erythropentofuranosyl azide

: 367518-86-3
6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 71.5 percent / pyridine / 12 h / 25 °C

2: 68 percent / pyridine / 25 °C

3: H₂ / Pd/CaCO₃ / ethanol / 2 h / 1034.32 Torr

4: 51 percent / diisopropylethylamine / ethanol / Heating

5: 98 percent / PyBOP; diisopropylethylamine / CH₂Cl₂ / 1 h / 0 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; Lindlar's catalyst; In pyridine; ethanol; dichloromethane;
DOI:10.1021/ja012135q

Reference yield:

: 367518-76-1
2-deoxy-3-O-dimethoxytrityl-5-O-tert-butyl(dimethyl)silyl-α,β-D-erythropentofuranosyl azide

: 367518-86-3
6-[2’-deoxy-3’-O-dimethoxytrityl-5’-O-tert-butyl(dimethyl)silyl-α,β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/CaCO₃ / ethanol / 2 h / 1034.32 Torr

2: 51 percent / diisopropylethylamine / ethanol / Heating

3: 98 percent / PyBOP; diisopropylethylamine / CH₂Cl₂ / 1 h / 0 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; Lindlar's catalyst; In ethanol; dichloromethane;
DOI:10.1021/ja012135q