tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate

Base Information

• Chemical Name: tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate
• CAS No.: 1174987-24-6
• Molecular Formula: C₂₃H₃₃NO₅
• Molecular Weight: 403.519
• Mol file: 1174987-24-6.mol

Synonyms:tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate

Chemical Property of tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate

There total 1 articles about tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(R,2E,4E)-8-tert-butoxy-4,6-dimethyl-8-oxoocta-2,4-dienoic acid (1174987-06-4) + (R)-tyrosinol hydrochloride (40829-04-7) → tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate (1174987-24-6)

Guidance literature:

(R,2E,4E)-8-tert-butoxy-4,6-dimethyl-8-oxoocta-2,4-dienoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;

(R)-tyrosinol hydrochloride; With triethylamine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol901277q

Reference yield: 93.0%

tert-butyl (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoate (1174987-24-6) → (R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoic acid: (1175565-77-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h;

DOI:10.1021/ol901277q

upstream raw materials:

(R,2E,4E)-8-tert-butoxy-4,6-dimethyl-8-oxoocta-2,4-dienoic acid

(R)-tyrosinol hydrochloride

Downstream raw materials:

(R,4E,6E)-8-((R)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3,5-dimethyl-8-oxoocta-4,6-dienoic acid: