Technology Process of 4-(2,8-bis(trifluoromethyl)quinolin-4-yl)benzonitrile
There total 3 articles about 4-(2,8-bis(trifluoromethyl)quinolin-4-yl)benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium carbonate;
In
1,4-dioxane; water;
at 110 ℃;
for 13h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: phosphorous; iodine; acetic acid / acetic acid / 10 h / 10 - 20 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium carbonate / 1,4-dioxane; water / 13 h / 110 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); phosphorous; tetrabutyl ammonium fluoride; iodine; sodium carbonate; acetic acid;
In
1,4-dioxane; water; acetic acid;
2: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: polyphosphoric acid / 2 h / 20 - 120 °C / Inert atmosphere
2: sodium hydroxide / acetone / 1 h / 10 °C / pH 7.5 / Inert atmosphere
3: phosphorous; iodine; acetic acid / acetic acid / 10 h / 10 - 20 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium carbonate / 1,4-dioxane; water / 13 h / 110 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); phosphorous; tetrabutyl ammonium fluoride; iodine; sodium carbonate; acetic acid; sodium hydroxide;
In
1,4-dioxane; water; acetic acid; acetone;
4: |Suzuki Coupling;
