1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol

Base Information

• Chemical Name: 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol
• CAS No.: 627077-80-9
• Molecular Formula: C₁₉H₂₆O₄
• Molecular Weight: 318.413
• Mol file: 627077-80-9.mol

Synonyms:1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol

Chemical Property of 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol

There total 5 articles about 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 5-hydroperoxy-4-methylene-1-phenyl-hexane-1,6-diol (627077-78-5) → 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol (627077-80-9)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2004.08.005

Reference yield:

(E)-6-acetoxy-4-methyl-4-hexenal (35334-60-2) → 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol (627077-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / diethyl ether / 3 h / 20 °C

2: 35 percent / O₂; methylene blue / acetonitrile / 6 h / Irradiation

3: 62 percent / TsOH*H₂O / CH₂Cl₂ / 1 h / 20 °C

With oxygen; methylene blue; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2004.08.005

Reference yield:

3-methyl-6-phenyl-hex-2-ene-1,6-diol (627077-77-4) → 1-phenyl-4-(1,2,5-trioxa-spiro[5.5]undec-3-yl)-pent-4-en-1-ol (627077-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / O₂; methylene blue / acetonitrile / 6 h / Irradiation

2: 62 percent / TsOH*H₂O / CH₂Cl₂ / 1 h / 20 °C

With oxygen; methylene blue; toluene-4-sulfonic acid; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2004.08.005

upstream raw materials:

cyclohexanone

5-hydroperoxy-4-methylene-1-phenyl-hexane-1,6-diol

(E)-6-acetoxy-4-methyl-4-hexenal

3-methyl-6-phenyl-hex-2-ene-1,6-diol