(1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol

Base Information

• Chemical Name: (1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol
• CAS No.: 83393-30-0
• Molecular Formula: C₂₁H₂₂F₃NO
• Molecular Weight: 361.407
• Mol file: 83393-30-0.mol

Synonyms:(1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol

Chemical Property of (1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol

There total 2 articles about (1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nortropinone (5632-84-8) → (1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol (83393-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 23 °C

2: tetrahydrofuran / -78 - 23 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2003.10.024

Reference yield:

N-benzyltropinone (28957-72-4) + 3-(trifluoromethyl)phenyllithium (368-49-0) → (1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol (83393-30-0)

Guidance literature:

In tetrahydrofuran; at -78 - 23 ℃;

DOI:10.1016/j.bmcl.2003.10.024

Reference yield:

(1S,3R,5R)-8-Benzyl-3-(3-trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol (83393-30-0) → (1S,3R,5R)-3-(3-Trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol (83393-43-5)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 50 ℃;

DOI:10.1016/j.bmcl.2003.10.024

upstream raw materials:

N-benzyltropinone

3-(trifluoromethyl)phenyllithium

nortropinone

Downstream raw materials:

(1S,3R,5R)-3-(3-Trifluoromethyl-phenyl)-8-aza-bicyclo[3.2.1]octan-3-ol