2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Base Information

Chemical Name:2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid
CAS No.:943740-40-7
Molecular Formula:C₂₈H₃₀N₄O₅S
Molecular Weight:534.636
Hs Code.:

Synonyms:2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Suppliers and Price of 2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

There total 12 articles about 2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 943740-40-7
2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Guidance literature:

Reference yield:

: 943740-39-4
2-(4-(4-(3-((tert-butoxycarbonylamino)methyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

: 943740-40-7
2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield:

: 22647-95-6
5-(4-bromophenyl)pentanoic acid

: 943740-40-7
2-(4-(4-(3-(aminomethyl)-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)-2-(4-cyanophenylamino)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

2: dmap; pyridine / dichloromethane / 14 h / 20 °C

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

4: 2,2'-iminobis[ethanol] / diethyl ether; dichloromethane; ethyl acetate; isopropyl alcohol / 20 °C

5: 1,2-dichloro-ethane / 100 °C / Microwave irradiation

6: hydrogenchloride / 1,4-dioxane; ethyl acetate / 20 °C

With pyridine; hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; 2,2'-iminobis[ethanol]; In 1,4-dioxane; diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.5b00788