2-(1-Phenylcyclopropyl)acetic acid

Base Information

• Chemical Name: 2-(1-Phenylcyclopropyl)acetic acid
• CAS No.: 7350-58-5
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• European Community (EC) Number: 855-151-2

Synonyms:2-(1-phenylcyclopropyl)acetic acid;7350-58-5;SCHEMBL1361875;2-(1-phenylcyclopropyl)aceticacid;VDILQNWKNNOSKJ-UHFFFAOYSA-N;(1-phenyl-cyclopropyl)-acetic acid;AKOS022300435;KS-10282;EN300-173302;Z1255374825

Chemical Property of 2-(1-Phenylcyclopropyl)acetic acid

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 200

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1(CC(=O)O)C2=CC=CC=C2

Technology Process of 2-(1-Phenylcyclopropyl)acetic acid

There total 2 articles about 2-(1-Phenylcyclopropyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-Phenyl-cyclopropyl)-acetic acid methyl ester (7306-15-2) → 2-(1-phenylcyclopropyl)acetic acid (7350-58-5)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1021/jo01347a063

Reference yield:

1-phenylcyclopropanecarbonyl chloride (63201-02-5) → 2-(1-phenylcyclopropyl)acetic acid (7350-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) /BRN= 102415/, (ii) /BRN= 1098229/, Et₃N, PhCO₂Ag

2: aq. KOH / ethanol / Heating

With potassium hydroxide; In ethanol;

DOI:10.1021/jo01347a063

Reference yield:

2-(1-phenylcyclopropyl)acetic acid (7350-58-5) → (1-Phenyl-cyclopropyl)acetylchlorid (7350-59-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1.5h;

upstream raw materials:

(1-Phenyl-cyclopropyl)-acetic acid methyl ester

1-phenylcyclopropanecarbonyl chloride

Downstream raw materials:

N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]-2-(1-phenylcyclopropyl)acetamide

(1-Phenyl-cyclopropyl)acetylchlorid

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