6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Base Information

Chemical Name:6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile
CAS No.:1378037-70-7
Molecular Formula:C₁₈H₁₀ClFN₆
Molecular Weight:364.769
Hs Code.:

Synonyms:6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Suppliers and Price of 6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

There total 5 articles about 6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1378039-39-4
4-chloro-2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridine

: 42182-27-4
4-cyanopyridin-2-amine

: 1378037-70-7
6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Guidance literature:: 4-cyanopyridin-2-amine; With sodium hydride; In N,N-dimethyl-formamide; at 150 ℃; for 0.25h; Sealed vial;

4-chloro-2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridine; Inert atmosphere; Sealed vial; Microwave irradiation;

Reference yield:

: 1378039-22-5
4-azidonicotinaldehyde

: 1378037-70-7
6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; titanium tetrachloride / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.1: toluene / 18 h / 105 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

4.1: tetrabutyl-ammonium chloride; trichlorophosphate / 5 h / 85 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 150 °C / Sealed vial

5.2: Inert atmosphere; Sealed vial; Microwave irradiation

With tetrabutyl-ammonium chloride; titanium tetrachloride; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1378039-36-1
[1-(4-azidopyridin-3-yl)meth-(E)-ylidene]-(2-chloro-6-fluorophenyl)amine

: 1378037-70-7
6-[2-(2-chloro-6-fluorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]isonicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 18 h / 105 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3.1: tetrabutyl-ammonium chloride; trichlorophosphate / 5 h / 85 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 150 °C / Sealed vial

4.2: Inert atmosphere; Sealed vial; Microwave irradiation

With tetrabutyl-ammonium chloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; toluene;