Technology Process of 2-Cyclopropyl-3-ethynyl-4-(4-fluoro-phenyl)-5-methyl-6-phenyl-pyridine
There total 8 articles about 2-Cyclopropyl-3-ethynyl-4-(4-fluoro-phenyl)-5-methyl-6-phenyl-pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
DOI:10.1021/jm00113a019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / piperidine, HOAc / benzene / 22 h / Heating
2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h
3: NH4OAc, Cu(OAc)2 / acetic acid / 24 h / Heating
4: LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
5: 79 percent / 4-methylmorpholine N-oxide, 4A molecular sieves, tetrapropylammonium perruthenate (TPAP) / CH2Cl2 / 0.5 h / Ambient temperature
6: triphenylphosphine / CH2Cl2 / 0.42 h / Ambient temperature
7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
With
piperidine; lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; copper diacetate; 4 A molecular sieve; ammonium acetate; acetic acid; 4-methylmorpholine N-oxide; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm00113a019
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h
2: NH4OAc, Cu(OAc)2 / acetic acid / 24 h / Heating
3: LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
4: 79 percent / 4-methylmorpholine N-oxide, 4A molecular sieves, tetrapropylammonium perruthenate (TPAP) / CH2Cl2 / 0.5 h / Ambient temperature
5: triphenylphosphine / CH2Cl2 / 0.42 h / Ambient temperature
6: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
With
lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; copper diacetate; 4 A molecular sieve; ammonium acetate; 4-methylmorpholine N-oxide; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019