5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid
CAS No.:847492-42-6
Molecular Formula:C₂₃H₃₁ClN₄O₅
Molecular Weight:478.976
Hs Code.:

Synonyms:5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

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Chemical Property of 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

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Technology Process of 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

There total 1 articles about 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 847492-48-2
tert-butyl {(3R)-1-[4-(2-chlorobenzyl)-3-formyl-1-(methoxymethyl)-1H-pyrazol-5-yl]piperidin-3-yl}carbamate

: 847492-49-3
C₂₃H₃₁ClN₄O₄

: 847492-43-7
C₂₃H₃₁ClN₄O₅

: 847492-42-6
5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 0 ℃; for 7h;

Reference yield:

: 847492-43-7
C₂₃H₃₁ClN₄O₅

: 847492-42-6
5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

: 41172-77-4
(±)-2-amino-3-oxo-butyric acid methyl ester hydrochloride

: 847492-20-0
methyl 2-({[5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazol-3-yl]carbonyl}amino)-3-oxobutanate

: 847492-21-1
C₂₈H₃₈ClN₅O₇

Guidance literature:: C₂₃H₃₁ClN₄O₅; 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.5h;

(±)-2-amino-3-oxo-butyric acid methyl ester hydrochloride; In tetrahydrofuran; at -20 - 20 ℃;

Reference yield:

: 847492-43-7
C₂₃H₃₁ClN₄O₅

: 847492-42-6
5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid

: dimethyl 3-oxoglutamate hydrochloride

: 847492-70-0
C₃₀H₄₀ClN₅O₉

: 847492-69-7
dimethyl N-{[5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazol-3-yl]carbonyl}-3-oxoglutamate

Guidance literature:: C₂₃H₃₁ClN₄O₅; 5-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-4-(2-chlorobenzyl)-1-(methoxymethyl)-1H-pyrazole-3-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.5h;

dimethyl 3-oxoglutamate hydrochloride; In tetrahydrofuran; at 20 ℃;