1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one

Base Information

• Chemical Name: 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one
• CAS No.: 723-74-0
• Molecular Formula: C₁₁H₉F₃N₂O
• Molecular Weight: 242.2
• Mol file: 723-74-0.mol

Synonyms:1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one

Chemical Property of 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one

There total 6 articles about 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (96145-98-1) + dimethyl sulfate (77-78-1) → 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one (723-74-0)

Guidance literature:

at 120 - 130 ℃; regioselective reaction;

DOI:10.1016/j.jfluchem.2017.12.011

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one (723-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / Reflux

2: 120 - 130 °C

With potassium carbonate; In ethanol;

DOI:10.1016/j.jfluchem.2017.12.011

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → 1-methyl-2-phenyl-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one (723-74-0) + 5-methoxy-1-phenyl-3-trifluoromethyl-1H-pyrazole

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / Reflux

2: potassium carbonate / methanol / Reflux

With potassium carbonate; In methanol; ethanol;

DOI:10.1016/j.jfluchem.2017.12.011

upstream raw materials:

3-trifluoromethyl-1-phenyl-1H-pyrazol-5(4H)-one

dimethyl sulfate

1-methyl-2-phenylhydrazine

ethyl 4,4,4-trifluoroacetoacetate