(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

Base Information

Chemical Name:(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide
CAS No.:1318114-57-6
Molecular Formula:Br*C₂₁H₃₀NO₃
Molecular Weight:424.378
Hs Code.:

Synonyms:(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

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Chemical Property of (1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

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Technology Process of (1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

There total 4 articles about (1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-83-9
methyl bromide

: 1318115-18-2
(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7-methyl-7-azabicyclo[2.2.1]heptane

: 1318114-57-6,84095-08-9
(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

Guidance literature:: In diethyl ether; acetone; at 20 ℃; for 48h;

Reference yield:

: 154905-39-2,152533-46-5,154905-36-9
(-)-exo-7-<(1,1-Domethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-ol

: 1318114-57-6,84095-08-9
(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / n-heptane; mineral oil / 20 h / 100 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

2.2: pH 10

3.1: water; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.1: diethyl ether; acetone / 48 h / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; sodium hydride; In 1,4-dioxane; diethyl ether; n-heptane; 1,2-dichloro-ethane; acetone; mineral oil;

Reference yield:

: 64471-47-2
(R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester

: 1318114-57-6,84095-08-9
(1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / n-heptane; mineral oil / 20 h / 100 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

2.2: pH 10

3.1: water; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.1: diethyl ether; acetone / 48 h / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; sodium hydride; In 1,4-dioxane; diethyl ether; n-heptane; 1,2-dichloro-ethane; acetone; mineral oil;