Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine
• CAS No.: 129789-66-8
• Molecular Formula: C₆H₁₅N*C₃₈H₃₈ClN₂O₈PS₂
• Molecular Weight: 882.479
• Mol file: 129789-66-8.mol

Synonyms:Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine

Chemical Property of Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine

There total 3 articles about Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5'-O-Dimethoxytritylthymidine-3'-O-<β-cyanoethyl-(S-4-chlorobenzyl)>-phosphorodithioate (129789-63-5) + triethylamine (121-44-8) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine (129789-66-8)

Guidance literature:

In acetonitrile; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88887-5

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] (98796-51-1) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine (129789-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) tetrazole, 2) sulfur, 2,6-lutidine / 1) CH₃CN, 40 min, 2) toluene, 1 h, rt

2: 72 percent / acetonitrile / 3 h / Ambient temperature

With 2,6-dimethylpyridine; 1H-tetrazole; sulfur; In acetonitrile;

DOI:10.1016/S0040-4039(00)88887-5

Reference yield:

(4-chlorophenyl)methanethiol (6258-66-8) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-benzyl) ester; compound with triethyl-amine (129789-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) tetrazole, 2) sulfur, 2,6-lutidine / 1) CH₃CN, 40 min, 2) toluene, 1 h, rt

2: 72 percent / acetonitrile / 3 h / Ambient temperature

With 2,6-dimethylpyridine; 1H-tetrazole; sulfur; In acetonitrile;

DOI:10.1016/S0040-4039(00)88887-5

upstream raw materials:

5'-O-Dimethoxytritylthymidine-3'-O-<β-cyanoethyl-(S-4-chlorobenzyl)>-phosphorodithioate

triethylamine

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

(4-chlorophenyl)methanethiol

Downstream raw materials:

O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> S-(4-chlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate