2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

Base Information

Chemical Name:2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide
CAS No.:1112849-67-8
Molecular Formula:C₂₃H₂₃ClN₂O₃
Molecular Weight:410.9
Hs Code.:

Synonyms:2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

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Chemical Property of 2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

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Technology Process of 2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

There total 4 articles about 2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1597403-93-4
methyl 2-chloro-5-(3,5-dimethylphenyl)pyridine-3-carboxylate

: 5763-61-1
3,4-dimethoxybenzylamine

: 1112849-67-8
2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

Guidance literature:: methyl 2-chloro-5-(3,5-dimethylphenyl)pyridine-3-carboxylate; With potassium trimethylsilonate; In tetrahydrofuran; at 20 - 25 ℃; for 24h; Inert atmosphere;

3,4-dimethoxybenzylamine; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 45 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201300447

Reference yield:

: 1112849-66-7
2-chloro-5-(3,5-dimethylphenyl)nicotinic acid

: 5763-61-1
3,4-dimethoxybenzylamine

: 1112849-67-8
2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

Guidance literature:: With chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃; for 20h;

Reference yield:

: 172975-69-8
3,5-dimethylphenyl boronic acid

: 1112849-67-8
2-chloro-N-(3,4-dimethoxybenzyl)-5-(3,5-dimethylphenyl)pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide; water / 18 h / 25 °C

2.1: potassium trimethylsilonate / tetrahydrofuran / 24 h / 20 - 25 °C / Inert atmosphere

2.2: 3 h / 45 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium trimethylsilonate; caesium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1002/cmdc.201300447