1-Phenyl-1-propanamine hydrochloride

Base Information

• Chemical Name: 1-Phenyl-1-propanamine hydrochloride
• CAS No.: 24301-86-8
• Molecular Formula: C9H13 N . Cl H
• Molecular Weight: 171.67
• Hs Code.: 2921499090
• DSSTox Substance ID: DTXSID30947136
• NSC Number: 32756
• Mol file: 24301-86-8.mol

Synonyms:1-PHENYL-1-PROPANAMINE HYDROCHLORIDE;24301-86-8;1-phenylpropan-1-amine hydrochloride;(R)-(+)-1-Amino-1-phenylpropaneHCl;1-PHENYL-1-PROPANAMINE HCL;1-phenylpropan-1-amine;hydrochloride;DTXSID30947136;1-PHENYL-1-PROPANAMINEHCL;GRVMJKAAXNELJW-UHFFFAOYSA-N;NSC32756;1-(phenyl)-propylamine hydrochloride;NSC-32756;AKOS005110947;SB45716;A4225;CS-0295770;EN300-270147;N12648;1-Phenylpropan-1-amine--hydrogen chloride (1/1)

Chemical Property of 1-Phenyl-1-propanamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.272mmHg at 25°C
• Boiling Point: 203.9°C at 760 mmHg
• Flash Point: 85.1°C
• PSA: 26.02000
• LogP: 3.59870
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 171.0814771
• Heavy Atom Count: 11
• Complexity: 84.7

Purity/Quality:

98%min ^*data from raw suppliers

1-Phenylpropan-1-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C1=CC=CC=C1)N.Cl

Technology Process of 1-Phenyl-1-propanamine hydrochloride

There total 11 articles about 1-Phenyl-1-propanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(α-aethylbenzyl)-benzolcarboximidsauremethylester → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + (α-aethylbenzyl)ammoniumchlorid (24301-86-8)

Guidance literature:

With hydrogenchloride; at 60 ℃; for 0.5h;

DOI:10.1002/hlca.19810640509

Reference yield:

phenylpropane (103-65-1) → amphetamine hydrochloride (2706-50-5,405-41-4) + (α-aethylbenzyl)ammoniumchlorid (24301-86-8)

Guidance literature:

phenylpropane; With Benzophenone imine; copper(l) iodide; 1,10-Phenanthroline; di-tert-butyl peroxide; In chlorobenzene; at 90 ℃; for 48h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; water; chlorobenzene; at 40 ℃; for 15h; Overall yield = 63 %; Overall yield = 54 mg; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b03505

Reference yield:

propiophenone oxime (2157-50-8) → (α-aethylbenzyl)ammoniumchlorid (24301-86-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; under 760.051 Torr;

upstream raw materials:

diethyl N-(1-phenylpropyl)phosphoramidate

N-(Diethoxyphosphoryl)benzylideneimine

N-benzyl-benzolcarboximidsauremethylester

N-(1-phenylpropyl)formamide

Downstream raw materials:

2-methyl-1-phenylprop-2-en-1-one

N⁶-[(+/-)-1-(phenyl)propyl]adenosine

(S)-N-benzoyl-1-phenylpropylamine

[formyl-(1-phenyl-propyl)-amino]-acetic acid methyl ester

Refernces

• 1、 Kramer, S?ren. "Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling". supporting information. p. 65 - 69. Retrieved 2019/01/04.
• 2、 -. "APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT". Paragraph 0164. . Retrieved 2018/10/27.