2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

Base Information

Chemical Name:2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran
CAS No.:159267-71-7
Molecular Formula:C₂₃H₂₇NO₄
Molecular Weight:381.472
Hs Code.:

Synonyms:2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

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Chemical Property of 2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

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Technology Process of 2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

There total 1 articles about 2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 159267-71-7
2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

: 2(S)-(N,N-dibenzylamino)-4(S)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

Guidance literature:: With n-butyllithium; air; carbon monoxide; Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1021/ja00101a014

Reference yield: 96.0%

: 159267-71-7
2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

: 159267-74-0
(3R,5R)-3-Dibenzylamino-5-((R)-1,2-dihydroxy-ethyl)-dihydro-furan-2-one

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/ja00101a014

Reference yield:

: 159267-71-7
2(R)-(N,N-dibenzylamino)-4(R)-(1,3-dioxa-2,2,-dimethylcyclopent-5(R)-yl)-1-oxotetrahydrofuran

: 159267-75-1
(3R,5R)-5-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-3-dibenzylamino-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / 1N aq. HCl / methanol; CH₂Cl₂ / 24 h / Ambient temperature

2: 82 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogenchloride; dmap; triethylamine; In methanol; dichloromethane;
DOI:10.1021/ja00101a014