Technology Process of (2R,4R)-2,4-diamino-1,5-diphenyl-3-hydroxypentane
There total 3 articles about (2R,4R)-2,4-diamino-1,5-diphenyl-3-hydroxypentane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,4R)-2,4-dibenzyl-3-hydroxypentanedioic acid;
With
dmap; diphenylphosphoranyl azide; triethylamine;
In
tetrahydrofuran;
at 65 ℃;
for 20h;
With
barium dihydroxide;
In
1,4-dioxane; water;
for 4h;
Heating;
DOI:10.1016/S0040-4020(02)00204-1
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / NaClO2, NaH2PO4, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O
2: Ru(OAc)2<(S)-BINAP>, NEt3, H2 / 90 h / 50 °C / 68400 Torr
3: 1.) DPPA, NEt3, DMAP, 2.) Ba(OH)2 / 1.) THF, reflux, 2.) dioxane, H2O, reflux
With
dmap; barium dihydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; diphenyl-phosphinic acid; hydrogen; triethylamine;
In
water; tert-butyl alcohol;
DOI:10.1021/jo961012z
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Ru(OAc)2<(S)-BINAP>, NEt3, H2 / 90 h / 50 °C / 68400 Torr
2: 1.) DPPA, NEt3, DMAP, 2.) Ba(OH)2 / 1.) THF, reflux, 2.) dioxane, H2O, reflux
With
dmap; barium dihydroxide; Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; diphenyl-phosphinic acid; hydrogen; triethylamine;
DOI:10.1021/jo961012z
