(2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

Base Information

Chemical Name:(2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone
CAS No.:135006-43-8
Molecular Formula:C₁₇H₂₂O₄
Molecular Weight:290.359
Hs Code.:

Synonyms:(2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

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Chemical Property of (2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

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Technology Process of (2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

There total 5 articles about (2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 135006-24-5,135095-32-8
(4R)-2,6-dimethylphenyl 6-carbomethoxy-2,4-dimethyl-3-hydroxyhexanoate

: 135006-43-8
(2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 8h; Heating;

Reference yield:

: 87518-82-9,135095-37-3,144732-83-2
(R)-(+)-methyl 5-<(benzyloxy)methoxy>-4-methylpent-2-enoate

: 135006-43-8
(2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 3percent methanolic HCl, H₂ / 10percent Pd/C / 12 h

2: 89 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.5 h / -78 °C

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 1 h

4: 91 percent / p-TsOH*H₂O / benzene / 8 h / Heating

With hydrogenchloride; oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; lithium diisopropyl amide; palladium on activated charcoal; In dichloromethane; benzene;

Reference yield:

: 51233-80-8
2,6-dimethylphenyl propionate

: 135006-43-8
(2S,3S,4R)-6-<(2,6-dimethylphenyl)carboxy>-5-hydroxy-4-methylheptanoic acid 1,5-lactone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 1 h

2: 91 percent / p-TsOH*H₂O / benzene / 8 h / Heating

With toluene-4-sulfonic acid; lithium diisopropyl amide; In benzene;