N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine
CAS No.:1421356-77-5
Molecular Formula:C₂₇H₂₁ClFN₅O₃
Molecular Weight:517.947
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

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Chemical Property of N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

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Technology Process of N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

There total 3 articles about N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

: 1421356-86-6
N-(3-chloro-4-fluorophenyl)-6-(5-formyl-2-furyl)-4-quinazolinamine

: 29968-78-3
2-(4-nitrophenyl)ethylamine monohydrochloride

: 1421356-77-5
N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

Guidance literature:: N-(3-chloro-4-fluorophenyl)-6-(5-formyl-2-furyl)-4-quinazolinamine; 2-(4-nitrophenyl)ethylamine monohydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 24h;

Reference yield:

: 5-formylfuran-2-boric acid

: 1421356-77-5
N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; palladium 10% on activated carbon / water; methanol; 1,2-dimethoxyethane / 24 h / 50 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2.2: 24 h / 0 °C

With palladium 10% on activated carbon; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 578737-95-8
N-(3-chloro-4-fluorophenyl)-6-iodo-4-quinazolinamine

: 1421356-77-5
N-(3-chloro-4-fluorophenyl)-6-(5-(((2-(4-nitrophenyl)ethyl)amino)methyl)-2-furyl)-4-quinazolinamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; palladium 10% on activated carbon / water; methanol; 1,2-dimethoxyethane / 24 h / 50 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2.2: 24 h / 0 °C

With palladium 10% on activated carbon; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;